A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis

José M.C. Ribeiro; André Vachereau; Govind B. Modi; Robert B. Tesh

doi:10.1126/science.2783496

A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis

José M.C. Ribeiro, André Vachereau, Govind B. Modi, Robert B. Tesh

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide.

Original language	English (US)
Pages (from-to)	212-214
Number of pages	3
Journal	Science
Volume	243
Issue number	4888
DOIs	https://doi.org/10.1126/science.2783496
State	Published - 1989
Externally published	Yes

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abstract = "Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide.",

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AU - Ribeiro, José M.C.

AU - Vachereau, André

AU - Modi, Govind B.

AU - Tesh, Robert B.

PY - 1989

Y1 - 1989

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AB - Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide.

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IS - 4888

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A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis

Abstract

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