TY - GEN
T1 - A MICROMACHINED DEVICE TO MEASURE SUBCELLULAR TRACTION FORCES
AU - Galbraith, Catherine G.
AU - Sheetz, Michael P.
N1 - Publisher Copyright:
© 1997 American Society of Mechanical Engineers (ASME). All rights reserved.
PY - 1997
Y1 - 1997
N2 - Cell migration is an essential part of embryogenesis, wound healing and immuno-logical responses. As cells migrate forward, they exert forces against their extracellular matrices through matrix ligands such as integrins. The forces depend upon the cell-substratum adhesion strength [1] and the ability of integrins to bind to the cytoskeleton. The forces also vary according to cell speed; faster moving cells exert less force than slower moving cells [2]. Determining the traction forces exerted by cells and how these forces can be modified has important implications in tissue engineering where enhanced migration speed and traction induced reorganization of the extracellular matrix can have a profound effect on cell invasion.
AB - Cell migration is an essential part of embryogenesis, wound healing and immuno-logical responses. As cells migrate forward, they exert forces against their extracellular matrices through matrix ligands such as integrins. The forces depend upon the cell-substratum adhesion strength [1] and the ability of integrins to bind to the cytoskeleton. The forces also vary according to cell speed; faster moving cells exert less force than slower moving cells [2]. Determining the traction forces exerted by cells and how these forces can be modified has important implications in tissue engineering where enhanced migration speed and traction induced reorganization of the extracellular matrix can have a profound effect on cell invasion.
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U2 - 10.1115/IMECE1997-0281
DO - 10.1115/IMECE1997-0281
M3 - Conference contribution
AN - SCOPUS:85126991120
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 167
EP - 168
BT - Advances in Bioengineering
PB - American Society of Mechanical Engineers (ASME)
T2 - ASME 1997 International Mechanical Engineering Congress and Exposition, IMECE 1997 - Advances in Bioengineering
Y2 - 16 November 1997 through 21 November 1997
ER -