A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel

Eszter Mária Horváth; Rita Mágenheim; Beatrix Annamária Domján; Viktória Ferencz; Tímea Tänczer; Eszter Szabó; Rita Benkő; Csaba Szabó; Ádám Tabák; Anikó Somogyi

doi:10.1556/650.2015.30307

A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel

Translated title of the contribution: The severity of gestational diabetes mellitus affects microvascular dysfunction measured three years after pregnancy that may be related to increased oxidative stress

Eszter Mária Horváth, Rita Mágenheim, Beatrix Annamária Domján, Viktória Ferencz, Tímea Tänczer, Eszter Szabó, Rita Benkő, Csaba Szabó, Ádám Tabák, Anikó Somogyi

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Introduction: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. Aim: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. Method: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. Results: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. Conclusions: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease.

Translated title of the contribution	The severity of gestational diabetes mellitus affects microvascular dysfunction measured three years after pregnancy that may be related to increased oxidative stress
Original language	Hungarian
Pages (from-to)	1932-1936
Number of pages	5
Journal	Orvosi hetilap
Volume	156
Issue number	47
DOIs	https://doi.org/10.1556/650.2015.30307
State	Published - Nov 2015

Keywords

Follow-up
Gestational diabetes
Oxidative stress
Vascular function

ASJC Scopus subject areas

General Medicine

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Horváth, E. M., Mágenheim, R., Domján, B. A., Ferencz, V., Tänczer, T., Szabó, E., Benkő, R., Szabó, C., Tabák, Á., & Somogyi, A. (2015). A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel. Orvosi hetilap, 156(47), 1932-1936. https://doi.org/10.1556/650.2015.30307

A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel. / Horváth, Eszter Mária; Mágenheim, Rita; Domján, Beatrix Annamária et al.
In: Orvosi hetilap, Vol. 156, No. 47, 11.2015, p. 1932-1936.

Research output: Contribution to journal › Article › peer-review

Horváth, EM, Mágenheim, R, Domján, BA, Ferencz, V, Tänczer, T, Szabó, E, Benkő, R, Szabó, C, Tabák, Á & Somogyi, A 2015, 'A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel', Orvosi hetilap, vol. 156, no. 47, pp. 1932-1936. https://doi.org/10.1556/650.2015.30307

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abstract = "Introduction: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. Aim: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. Method: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. Results: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. Conclusions: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease.",

keywords = "Follow-up, Gestational diabetes, Oxidative stress, Vascular function",

author = "Horv{\'a}th, {Eszter M{\'a}ria} and Rita M{\'a}genheim and Domj{\'a}n, {Beatrix Annam{\'a}ria} and Vikt{\'o}ria Ferencz and T{\'i}mea T{\"a}nczer and Eszter Szab{\'o} and Rita Benk{\H o} and Csaba Szab{\'o} and {\'A}d{\'a}m Tab{\'a}k and Anik{\'o} Somogyi",

year = "2015",

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doi = "10.1556/650.2015.30307",

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pages = "1932--1936",

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T1 - A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel

AU - Horváth, Eszter Mária

AU - Mágenheim, Rita

AU - Domján, Beatrix Annamária

AU - Ferencz, Viktória

AU - Tänczer, Tímea

AU - Szabó, Eszter

AU - Benkő, Rita

AU - Szabó, Csaba

AU - Tabák, Ádám

AU - Somogyi, Anikó

PY - 2015/11

Y1 - 2015/11

N2 - Introduction: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. Aim: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. Method: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. Results: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. Conclusions: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease.

AB - Introduction: Oxidative-nitrative stress and poly(ADP-ribose) polymerase activation observed in gestational diabetes may play role in the increased cardiovascular risk in later life. Aim: The present study aimed to examine the influence of the severity of previous gestational diabetes (insulin need) on vascular function three years after delivery. Furthermore, the authors investigated the relation of vascular function with oxidative-nitrative stress and poly(ADP-ribose) polymerase activation. Method: Macrovascular function was measured by applanation tonometry; microvascular reactivity was assessed by provocation tests during Laser-Doppler flowmetry in 40 women who had gestational diabetes 3 years before the study. Oxidative-nitrative stress and poly(ADP-ribose) polymerase activity in blood components were determined by colorimetry and immunohistochemistry. Results: Three years after insulin treated gestational diabetes impaired microvascular function and increased oxidative stress was observed compared to mild cases. Conclusions: The severity of previous gestational diabetes affects microvascular dysfunction that is accompanied by elevated oxidative stress. Nitrative stress and poly(ADP-ribose) polymerase activity correlates with certain vascular factors not related to the severity of the disease.

KW - Follow-up

KW - Gestational diabetes

KW - Oxidative stress

KW - Vascular function

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A gestatiós diabetes mellitus súlyossága befolyásolja a három évvel a szülést követoen mért microvascularis diszfunkció mértékét, amely kapcsolatban állhat az emelkedett szisztémás oxidatív stresszel

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