TY - JOUR
T1 - A comparison of the radiation sensitivities of non-tumorigenic and tumorigenic human hybrid cell lines
AU - Colman, M.
AU - Bhatt, S.
AU - Candelaria, M.
AU - Sun, C.
AU - Redpath, J. L.
N1 - Funding Information:
Acknowledgements Support for this research from NIH Grant 39312, the Phi Beta Psi Sorority, and the Division of Radiation Oncology, UC Irvine is gratefully acknowledged . We thank Dr Eric J . Stanbridge (Department of Microbiology and Molecular Genetics at UC Irvine) for provision of the cell lines and for helpful discussion .
PY - 1988
Y1 - 1988
N2 - The radiation sensitivities of two related non-tumorigenic and two related tumorigenic human hybrid cell lines (HeLa × skin fibroblast) have been studied. The data show that the transformation from the non-tumorigenic to the tumorigenic state, which is accompanied by the loss of skin fibroblast chromosomes 11 and 14, is not associated with any major changes in radiation sensitivity. The data do indicate, however, a trend toward a steeper and longer initial slope to the cell survival curve for the tumorigenic cell lines, along with a subsequent reduced ability to accumulate sublethal radiation injury at low doses. Both non-tumorigenic and tumorigenic cell lines have the capability of repairing sublethal injury.
AB - The radiation sensitivities of two related non-tumorigenic and two related tumorigenic human hybrid cell lines (HeLa × skin fibroblast) have been studied. The data show that the transformation from the non-tumorigenic to the tumorigenic state, which is accompanied by the loss of skin fibroblast chromosomes 11 and 14, is not associated with any major changes in radiation sensitivity. The data do indicate, however, a trend toward a steeper and longer initial slope to the cell survival curve for the tumorigenic cell lines, along with a subsequent reduced ability to accumulate sublethal radiation injury at low doses. Both non-tumorigenic and tumorigenic cell lines have the capability of repairing sublethal injury.
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U2 - 10.1080/09553008814550931
DO - 10.1080/09553008814550931
M3 - Article
C2 - 3258295
AN - SCOPUS:0023916276
SN - 0955-3002
VL - 53
SP - 609
EP - 616
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 4
ER -