A brief survey of mRNA surveillance

Ambro Van Hoof; Eric J. Wagner

doi:10.1016/j.tibs.2011.07.005

A brief survey of mRNA surveillance

Ambro Van Hoof, Eric J. Wagner

Biochemistry & Molecular Biology

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.

Original language	English (US)
Pages (from-to)	585-592
Number of pages	8
Journal	Trends in biochemical sciences
Volume	36
Issue number	11
DOIs	https://doi.org/10.1016/j.tibs.2011.07.005
State	Published - Nov 2011

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/j.tibs.2011.07.005

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title = "A brief survey of mRNA surveillance",

abstract = "Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.",

author = "{Van Hoof}, Ambro and Wagner, {Eric J.}",

note = "Funding Information: We thank Allan Jacobson, Aaron Goldstrohm, Phillip Carpenter, the van Hoof laboratory and the Wagner laboratory for insightful comments. Work in the van Hoof laboratory is supported by grants from NIH (RO1GM069900), NSF (1020739) and the Welch Foundation (AU-1773). Work in the Wagner laboratory is supported by grants from the NIH (1R21NS0676601 and 5R00GM080447). ",

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AU - Wagner, Eric J.

N1 - Funding Information: We thank Allan Jacobson, Aaron Goldstrohm, Phillip Carpenter, the van Hoof laboratory and the Wagner laboratory for insightful comments. Work in the van Hoof laboratory is supported by grants from NIH (RO1GM069900), NSF (1020739) and the Welch Foundation (AU-1773). Work in the Wagner laboratory is supported by grants from the NIH (1R21NS0676601 and 5R00GM080447).

PY - 2011/11

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N2 - Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.

AB - Defective mRNAs are degraded more rapidly than normal mRNAs in a process called mRNA surveillance. Eukaryotic cells use a variety of mechanisms to detect aberrations in mRNAs and a variety of enzymes to preferentially degrade them. Recent advances in the field of RNA surveillance have provided new information regarding how cells determine which mRNA species should be subject to destruction and novel mechanisms by which a cell tags an mRNA once such a decision has been reached. In this review, we highlight recent progress in our understanding of these processes.

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A brief survey of mRNA surveillance

Abstract

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