8-Oxoguanine DNA glycosylase 1: Beyond repair of the oxidatively modified base lesions

Xueqing Ba, lstvan Boldogh

Research output: Contribution to journalReview articlepeer-review

Abstract

Oxidative stress and the resulting damage to genomic DNA are inevitable consequences of endogenous physiological processes, and they are amplified by cellular responses to environmental exposures. One of the most frequent reactions of reactive oxygen species with DNA is the oxidation of guanine to pre-mutagenic 8-oxo-7,8-dihydroguanine (8-oxoG). Despite the vulnerability of guanine to oxidation, vertebrate genes are primarily embedded in GC-rich genomic regions, and over 72% of the promoters of human genes belong to a class with a high GC content. In the promoter, 8-oxoG may serve as an epigenetic mark, and when complexed with the oxidatively inactivated repair enzyme 8-oxoguanine DNA glycosylase 1, provide a platform for the coordination of the initial steps of DNA repair and the assembly of the transcriptional machinery to launch the prompt and preferential expression of redox-regulated genes. Deviations/variations from this artful coordination may be the etiological links between guanine oxidation and various cellular pathologies and diseases during ageing processes.

Original languageEnglish (US)
Pages (from-to)669-678
Number of pages10
JournalRedox Biology
Volume14
DOIs
StatePublished - Apr 2018

Keywords

  • 8-oxoguanine
  • DNA methylation
  • Epigenetic
  • Gene expression regulation
  • OGG1

ASJC Scopus subject areas

  • Organic Chemistry

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