5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

Pablo A. Valdes; Matthias Millesi; Georg Widhalm; David W. Roberts

doi:10.1007/s11060-018-03079-7

5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

Pablo A. Valdes, Matthias Millesi, Georg Widhalm, David W. Roberts

Research output: Contribution to journal › Review article › peer-review

Abstract

Introduction: 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors. Methods: Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas. Results: We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas. Conclusions: The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.

Original language	English (US)
Pages (from-to)	555-565
Number of pages	11
Journal	Journal of Neuro-Oncology
Volume	141
Issue number	3
DOIs	https://doi.org/10.1007/s11060-018-03079-7
State	Published - Feb 15 2019
Externally published	Yes

Keywords

5-Aminolevulinic acid
Fluorescence-guided surgery
Meningioma
Protoporphyrin IX
Quantitative fluorescence
Spectroscopy

ASJC Scopus subject areas

Oncology
Neurology
Clinical Neurology
Cancer Research

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10.1007/s11060-018-03079-7

Cite this

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title = "5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery",

abstract = "Introduction: 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors. Methods: Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas. Results: We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas. Conclusions: The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.",

keywords = "5-Aminolevulinic acid, Fluorescence-guided surgery, Meningioma, Protoporphyrin IX, Quantitative fluorescence, Spectroscopy",

author = "Valdes, {Pablo A.} and Matthias Millesi and Georg Widhalm and Roberts, {David W.}",

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T1 - 5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

AU - Valdes, Pablo A.

AU - Millesi, Matthias

AU - Widhalm, Georg

AU - Roberts, David W.

PY - 2019/2/15

Y1 - 2019/2/15

N2 - Introduction: 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors. Methods: Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas. Results: We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas. Conclusions: The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.

AB - Introduction: 5-aminolevulinic acid induced protoporphyrin IX (5-ALA-PpIX) fluorescence guidance has emerged as a valuable surgical adjunct for resection of intracranial tumors. Methods: Here we present a focused review on 5-ALA-PpIX fluorescence guidance for meningiomas. Results: We discuss the clinical studies and specific applications to date as well as the two main intraoperative fluorescence technologies applied to meningiomas. Conclusions: The use of 5-ALA-PpIX in meningiomas holds promising potential so neurosurgeons can improve surgical outcomes for patients with meningiomas as well as be pioneers in developing improved fluorescence imaging technologies.

KW - 5-Aminolevulinic acid

KW - Fluorescence-guided surgery

KW - Meningioma

KW - Protoporphyrin IX

KW - Quantitative fluorescence

KW - Spectroscopy

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5-aminolevulinic acid induced protoporphyrin IX (ALA-PpIX) fluorescence guidance in meningioma surgery

Abstract

Keywords

ASJC Scopus subject areas

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