2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Amy E. Lusska; Keith W. Jones; Cornelis J. Elferink; Lena Wu; Emily S. Shen; Long Ping Wen; James P. Whitlock

doi:10.1016/0065-2571(91)90019-I

2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Amy E. Lusska, Keith W. Jones, Cornelis J. Elferink, Lena Wu, Emily S. Shen, Long Ping Wen, James P. Whitlock

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.

Original language	English (US)
Pages (from-to)	307-317
Number of pages	11
Journal	Advances in Enzyme Regulation
Volume	31
Issue number	C
DOIs	https://doi.org/10.1016/0065-2571(91)90019-I
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Genetics
Cancer Research

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10.1016/0065-2571(91)90019-I

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title = "2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene",

abstract = "We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.",

author = "Lusska, {Amy E.} and Jones, {Keith W.} and Elferink, {Cornelis J.} and Lena Wu and Shen, {Emily S.} and Wen, {Long Ping} and Whitlock, {James P.}",

note = "Funding Information: Supported by research grants from the American Cancer Society, the National Cancer Institute, and the National Institute of Environmental Health Sciences.",

year = "1991",

doi = "10.1016/0065-2571(91)90019-I",

language = "English (US)",

volume = "31",

pages = "307--317",

journal = "Advances in Enzyme Regulation",

issn = "0065-2571",

publisher = "Elsevier Ltd",

number = "C",

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TY - JOUR

T1 - 2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

AU - Lusska, Amy E.

AU - Jones, Keith W.

AU - Elferink, Cornelis J.

AU - Wu, Lena

AU - Shen, Emily S.

AU - Wen, Long Ping

AU - Whitlock, James P.

N1 - Funding Information: Supported by research grants from the American Cancer Society, the National Cancer Institute, and the National Institute of Environmental Health Sciences.

PY - 1991

Y1 - 1991

N2 - We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.

AB - We have reviewed the transcriptional regulation of the CYP1A1 gene, which encodes the cytochrome P450IA1 enzyme. TCDD induces CYP1A1 transcription via a receptor- and enhancer-dependent mechanism that involves multiple protein-DNA interactions. The system provides an example of enzyme regulation at the level of gene transcription.

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UR - http://www.scopus.com/inward/citedby.url?scp=0026038699&partnerID=8YFLogxK

U2 - 10.1016/0065-2571(91)90019-I

DO - 10.1016/0065-2571(91)90019-I

M3 - Article

C2 - 1652189

AN - SCOPUS:0026038699

SN - 0065-2571

VL - 31

SP - 307

EP - 317

JO - Advances in Enzyme Regulation

JF - Advances in Enzyme Regulation

IS - C

ER -

2,3,7,8-tetrachlorodibenzo-P-dioxin induces cytochrome P450IA1 enzyme activity by activating transcription of the corresponding gene

Abstract

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