Abstract
This study examined 2',5'-oligoadenylate (2,5A) synthetase activity in 26 individuals during the asymptomatic phase of HIV infection and its correlation with neopterin or β2-microglobulin. In HIV-antibody-positive (HIV-Ab+) asymptomatic people, both neopterin and β2-microglobulin levels in sera were significantly elevated; in contrast, 2,5A-synthetase activity in peripheral blood mononuclear cells was not significantly higher than in HIV-antibody-negative controls. The 2,5A-synthetase levels in symptomatic people (AIDS-related complex and AIDS) were significantly higher than in either asymptomatic or control individuals. However, within the group of HIV-infected asymptomatic individuals, all three markers were positively correlated. In this group, neopterin values were negatively correlated with the number of CD4+ lymphocytes while a positive correlation was found between 2,5A-synthetase and the number of CD8+ lymphocytes. Asymptomatic people with detectable serum HIV p24 antigen had significantly higher 2,5A-synthetase, neopterin, β2-microglobulin and number of CD8+ lymphocytes. This study suggests that elevated 2,5A-synthetase activity may reflect a different aspect of host response to HIV infection than do elevated neopterin or β2-microglobulin.
Original language | English (US) |
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Pages (from-to) | 289-293 |
Number of pages | 5 |
Journal | AIDS |
Volume | 5 |
Issue number | 3 |
DOIs | |
State | Published - 1991 |
Externally published | Yes |
Keywords
- 2',5'-oligoadenylate synthetase
- AIDS
- asymptomatic
- CD4+ lymphocytes
- neopterin
- β-microglobulin
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases