Projects per year
Personal profile
Research Strategic Pillar
Dr. Randall Urban, VP and Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):
Personal profile
Division: Vaccinology
Dr. Pyles in a Professor in the Department of Pediatrics and Microbiology & Immunology and co-Director of the UTMB Assay Development Services Division in the Galveston National Lab. He received his B.A. in Biology and Chemistry from Hanover College, Indiana. He received his PhD in Molecular Genetics and Biochemistry & Microbiology from the University of Cincinnati College of Medicine. He completed his postdoctoral fellowship in the Department of Cell Biology, Neurobiology and Anatomy at the University of Cincinnati. ?He joined UTMB in 2000 as part of the establishment of the Sealy Center for Vaccine Development.
Dr. Pyles’ research interests focus on the interaction of host mucosae with the bacterial communities (microbiome) and pathogens that dramatically impact human health.? His career has been primarily focused on improving women’s health including study of sexually-transmitted infections. He is currently involved in preclinical and clinical studies of devices and interventions that increase ease of use and efficacy of next generation therapies.? Recent work has led to the establishment of novel systems to study both vaginal and nasal human mucosae after colonization by transplanted microbiome communities.
Research Strategic Pillar Keywords
- Brain Health
- Life Span Health
- Infectious/ Immunological Health
- Specialized Health
- Metabolic Health
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Collaborations and top research areas from the last five years
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Translational studies of the fecal microbiome associated with BIAFAC
Pyles, R. (PI)
Glenn Greenberg and Linda Vester Foundation
1/1/22 → 12/31/24
Project: Research project
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The Dynamics of Nasal Bacterial Ecology and S. aureus Antagonism
Pyles, R. (PI)
6/1/16 → 5/31/20
Project: Research project
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EL II: Anti-HIV/SHIV Efficacy of Combination Antiretroviral Intravaginal Rings
Pyles, R. (PI)
OAK CREST INSTITUTE OF SCIENCE
8/11/14 → 7/31/19
Project: Research project
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Validation of vaginal microbiome proxies for in vitro experiments that biomimic Lactobacillus-dominant vaginal cultures
Zahra, A., Menon, R., Bento, G. F. C., Selim, J., Taylor, B. D., Vincent, K. L., Pyles, R. B. & Richardson, L. S., Dec 2023, In: American Journal of Reproductive Immunology. 90, 6, e13797.Research output: Contribution to journal › Article › peer-review
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The arrival of SARS-CoV-2–neutralizing antibodies in a currently available commercial immunoglobulin
Miller, A. L., Rider, N. L., Pyles, R. B., Judy, B., Xie, X., Shi, P.-Y. & Ksiazek, T. G., Jun 2022, In: Journal of Allergy and Clinical Immunology. 149, 6, p. 1958-1959 2 p.Research output: Contribution to journal › Letter › peer-review
Open Access -
Microbiota Associated With Cholesteatoma Tissue in Chronic Suppurative Otitis Media
Frank, D. N., Magno, J. P. M., Velasco, K. J. S., Bootpetch, T. C., Salud, J. E. D., David, K. J. V., Miller, A. L., Yee, E. C., Dulnuan, H. P., Pyles, R. B., Lacuata, J. A. C., Arbizo, J. L., Kofonow, J. M., Guce, B., Mendoza, K. M. D., Robertson, C. E., Ilustre, G. M. S., Chiong, A. N. E., Lu, S. L. & Tongol, E. A. & 4 others, , Apr 19 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 746428.Research output: Contribution to journal › Article › peer-review
Open Access -
Outbreak of coronavirus disease 2019 (COVID-19) among operating room staff of a tertiary referral center: An epidemiologic and environmental investigation
McDougal, A. N., Elhassani, D., Demaet, M. A., Shores, S., Plante, K. S., Plante, J., Pyles, R., Weaver, S. C., Williams-Bouyer, N., Tyler, B. J., Davis, H. R. & Patel, J., Mar 19 2022, In: Infection control and hospital epidemiology. 43, 3, p. 319-325 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Generation and characterization of human Fetal membrane and Decidual cell lines for reproductive biology experiments
Radnaa, E., Urrabaz-Garza, R., Elrod, N. D., De Castro Silva, M., Pyles, R., Han, A. & Menon, R., Mar 1 2022, In: Biology of reproduction. 106, 3, p. 568-582 15 p.Research output: Contribution to journal › Article › peer-review
Open Access