Research output per year
Research output per year
- 1 - 50 out of 102 results
Search results
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2023
Characterization of an air-liquid interface primary human vaginal epithelium to study Ebola virus infection and testing of antivirals
Escaffre, O., Popov, V., Hager, E. & Freiberg, A. N., Mar 2023, In: Antiviral research. 211, 105551.Research output: Contribution to journal › Article › peer-review
Open Access -
Differences in Genetic Diversity of Mammalian Tick-Borne Flaviviruses
Carpio, K. L., Thompson, J. K., Widen, S. G., Smith, J. K., Juelich, T. L., Clements, D. E., Freiberg, A. N. & Barrett, A. D. T., Feb 2023, In: Viruses. 15, 2, 281.Research output: Contribution to journal › Article › peer-review
Open Access -
The prophylactic and therapeutic efficacy of the broadly active antiviral ribonucleoside N4-Hydroxycytidine (EIDD-1931) in a mouse model of lethal Ebola virus infection
Bluemling, G. R., Mao, S., Natchus, M. G., Painter, W., Mulangu, S., Lockwood, M., De La Rosa, A., Brasel, T., Comer, J. E., Freiberg, A. N., Kolykhalov, A. A. & Painter, G. R., Jan 2023, In: Antiviral research. 209, 105453.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Evaluations of rationally designed rift valley fever vaccine candidate RVax-1 in mosquito and rodent models
Ikegami, T., Jurado-Cobena, E., Alkan, C., Smith, J. K., Zhang, L., Kalveram, B., Juelich, T. L., Esterly, A. T., Bhaskar, J. R., Thangamani, S. & Freiberg, A. N., Dec 2022, In: npj Vaccines. 7, 1, 109.Research output: Contribution to journal › Article › peer-review
Open Access -
Powassan Virus Induces Structural Changes in Human Neuronal Cells In Vitro and Murine Neurons In Vivo
Nelson, J., Ochoa, L., Villareal, P., Dunn, T., Wu, P., Vargas, G. & Freiberg, A. N., Oct 2022, In: Pathogens. 11, 10, 1218.Research output: Contribution to journal › Article › peer-review
Open Access -
Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly
van Tol, S., Kalveram, B., Ilinykh, P. A., Ronk, A., Huang, K., Aguilera-Aguirre, L., Bharaj, P., Hage, A., Atkins, C., Giraldo, M. I., Wakamiya, M., Gonzalez-Orozco, M., Warren, A. N., Bukreyev, A., Freiberg, A. N. & Rajsbaum, R., May 2022, In: PLoS pathogens. 18, 5, e1010532.Research output: Contribution to journal › Article › peer-review
Open Access -
The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
Hage, A., Bharaj, P., van Tol, S., Giraldo, M. I., Gonzalez-Orozco, M., Valerdi, K. M., Warren, A. N., Aguilera-Aguirre, L., Xie, X., Widen, S., Moulton, H. M., Lee, B., Johnson, J. R., Krogan, N. J., García-Sastre, A., Shi, P.-Y., Freiberg, A. N. & Rajsbaum Gorodezky, R., Mar 8 2022, In: Cell Reports. 38, 10, 110434.Research output: Contribution to journal › Article › peer-review
Open Access -
Tilorone-dihydrochloride protects against rift valley fever virus infection and disease in the mouse model
Johnson, K. N., Kalveram, B., Smith, J. K., Zhang, L., Juelich, T., Atkins, C., Ikegami, T. & Freiberg, A. N., Jan 2022, In: Microorganisms. 10, 1, 92.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity
Covés-Datson, E. M., King, S. R., Legendre, M., Swanson, M. D., Gupta, A., Claes, S., Meagher, J. L., Boonen, A., Zhang, L., Kalveram, B., Raglow, Z., Freiberg, A. N., Prichard, M., Stuckey, J. A., Schols, D. & Markovitz, D. M., Dec 2021, In: Scientific reports. 11, 1, 656.Research output: Contribution to journal › Article › peer-review
Open Access -
Polyphenylene carboxymethylene (PPCM) microbicide repurposed as antiviral against SARS-CoV-2. Proof of concept in primary human undifferentiated epithelial cells
Escaffre, O. & Freiberg, A. N., Oct 2021, In: Antiviral research. 194, 105162.Research output: Contribution to journal › Article › peer-review
Open Access -
Rift valley fever virus 78kda envelope protein attenuates virus replication in macrophage-derived cell lines and viral virulence in mice
Terasaki, K., Kalveram, B., Johnson, K. N., Juelich, T., Smith, J. K., Zhang, L., Freiberg, A. N. & Makino, S., Sep 2021, In: PLoS neglected tropical diseases. 15, 9, e0009785.Research output: Contribution to journal › Article › peer-review
Open Access -
Stat-1 knockout mice as a model for wild-type sudan virus (Sudv)
Escaffre, O., Juelich, T. L., Neef, N., Massey, S., Smith, J., Brasel, T., Smith, J. K., Kalveram, B., Zhang, L., Perez, D., Ikegami, T., Freiberg, A. N. & Comer, J. E., Jul 2021, In: Viruses. 13, 7, 1388.Research output: Contribution to journal › Article › peer-review
Open Access -
Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors
Plewe, M. B., Gantla, V. R., Sokolova, N. V., Shin, Y. J., Naik, S., Brown, E. R., Fetsko, A., Zhang, L., Kalveram, B., Freiberg, A. N., Henkel, G. & McCormack, K., Jun 1 2021, In: Bioorganic and Medicinal Chemistry Letters. 41, 127983.Research output: Contribution to journal › Article › peer-review
Open Access -
Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition
Chapman, N. S., Zhao, H., Kose, N., Westover, J. B., Kalveram, B., Bombardi, R., Rodriguez, J., Sutton, R., Genualdi, J., LaBeaud, A. D., Mutuku, F. M., Pittman, P. R., Freiberg, A. N., Gowen, B. B., Fremont, D. H. & Crowe, J. E., Apr 6 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 14, e2025642118.Research output: Contribution to journal › Article › peer-review
Open Access -
Spike mutation D614G alters SARS-CoV-2 fitness
Plante, J. A., Liu, Y., Liu, J., Xia, H., Johnson, B. A., Lokugamage, K. G., Zhang, X., Muruato, A. E., Zou, J., Fontes-Garfias, C. R., Mirchandani, D., Scharton, D., Bilello, J. P., Ku, Z., An, Z., Kalveram, B., Freiberg, A. N., Menachery, V. D., Xie, X. & Plante, K. S. & 2 others, , Apr 1 2021, In: Nature. 592, 7852, p. 116-121 6 p.Research output: Contribution to journal › Article › peer-review
Open Access135 Scopus citations -
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Johnson, B. A., Xie, X., Bailey, A. L., Kalveram, B., Lokugamage, K. G., Muruato, A., Zou, J., Zhang, X., Juelich, T., Smith, J. K., Zhang, L., Bopp, N., Schindewolf, C., Vu, M., Vanderheiden, A., Winkler, E. S., Swetnam, D., Plante, J. A., Aguilar, P. & Plante, K. S. & 13 others, , Mar 11 2021, In: Nature. 591, 7849, p. 293-299 7 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
Inhibition of innate immune response ameliorates zika virus-induced neurogenesis deficit in human neural stem cells
Xu, P., Gao, J., Shan, C., Dunn, T. J., Xie, X., Xia, H., Zou, J., Thames, B. H., Sajja, A., Yu, Y., Freiberg, A. N., Vasilakis, N., Shi, P.-Y., Weaver, S. C. & Wu, P., Mar 2021, In: PLoS neglected tropical diseases. 15, 3, e0009183.Research output: Contribution to journal › Article › peer-review
Open Access -
SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species
Moustaqil, M., Ollivier, E., Chiu, H. P., Van Tol, S., Rudolffi-Soto, P., Stevens, C., Bhumkar, A., Hunter, D. J. B., Freiberg, A. N., Jacques, D., Lee, B., Sierecki, E. & Gambin, Y., 2021, In: Emerging Microbes and Infections. 10, 1, p. 178-195 18 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
2020
Pyronaridine tetraphosphate efficacy against Ebola virus infection in guinea pig
Lane, T. R., Massey, C., Comer, J. E., Freiberg, A. N., Zhou, H., Dyall, J., Holbrook, M. R., Anantpadma, M., Davey, R. A., Madrid, P. B. & Ekins, S., Sep 2020, In: Antiviral research. 181, 104863.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors
Plewe, M. B., Sokolova, N. V., Gantla, V. R., Brown, E. R., Naik, S., Fetsko, A., Lorimer, D. D., Lorimer, D. D., Dranow, D. M., Dranow, D. M., Smutney, H., Smutney, H., Bullen, J., Bullen, J., Sidhu, R., Sidhu, R., Master, A., Master, A., Wang, J. & Wang, J. & 6 others, , Jun 11 2020, In: ACS Medicinal Chemistry Letters. 11, 6, p. 1160-1167 8 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism
Takadate, Y., Kondoh, T., Igarashi, M., Maruyama, J., Manzoor, R., Ogawa, H., Kajihara, M., Furuyama, W., Sato, M., Miyamoto, H., Yoshida, R., Hill, T. E., Freiberg, A. N., Feldmann, H., Marzi, A. & Takada, A., Jan 14 2020, In: Cell Reports. 30, 2, p. 308-319.e5Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
VAMP8 contributes to the TRIM6-mediated type I interferon antiviral response during West Nile virus infection
Van Tol, S., Atkins, C., Bharaj, P., Johnson, K. N., Hage, A., Freiberg, A. N. & Rajsbaum, R., Jan 1 2020, In: Journal of virology. 94, 2, e01454-19.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2019
SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors
Plewe, M. B., Whitby, L. R., Naik, S., Brown, E. R., Sokolova, N. V., Gantla, V. R., York, J., Nunberg, J. H., Zhang, L., Kalveram, B., Freiberg, A. N., Boger, D. L., Henkel, G. & McCormack, K., Nov 15 2019, In: Bioorganic and Medicinal Chemistry Letters. 29, 22, 126620.Research output: Contribution to journal › Article › peer-review
Open Access -
Peptidoglycan-associated cyclic lipopeptide disrupts viral infectivity
Johnson, B. A., Hage, A., Kalveram, B., Mears, M., Plante, J., Rodriguez, S. E., Ding, Z., Luo, X., Bente, D., Bradrick, S., Freiberg, A. N., Popov, V., Rajsbaum Gorodezky, R., Rossi, S., Russell, W. K. & Menachery, V. D., Nov 1 2019, In: Journal of virology. 93, 22, e01282-19.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Polyphenylene carboxymethylene (PPCM) in vitro antiviral efficacy against Ebola virus in the context of a sexually transmitted infection
Escaffre, O., Juelich, T. L. & Freiberg, A. N., Oct 2019, In: Antiviral research. 170, 104567.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Henipavirus infection of the central nervous system
Dawes, B. E. & Freiberg, A. N., Mar 1 2019, In: Pathogens and disease. 77, 2, ftz023.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Filovirus virulence in interferon α/β and γ double knockout mice, and treatment with favipiravir
Comer, J. E., Escaffre, O., Neef, N., Brasel, T., Juelich, T. L., Smith, J. K., Smith, J., Kalveram, B., Perez, D. D., Massey, S., Zhang, L. & Freiberg, A. N., Feb 2019, In: Viruses. 11, 2, 137.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Repurposing quinacrine against Ebola virus infection in vivo
Lane, T. R., Comer, J. E., Freiberg, A. N., Madrid, P. B. & Ekins, S., 2019, In: Antimicrobial agents and chemotherapy. 63, 9, e01142-19.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2018
A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice
Terasaki, K., Juelich, T. L., Smith, J. K., Kalveram, B., Perez, D. D., Freiberg, A. N. & Makino, S., Dec 1 2018, In: Scientific reports. 8, 1, 17097.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Favipiravir (T-705) protects against Nipah virus infection in the hamster model /631/326/22/1295 /631/326/596/1296 /13/106 /14/35 /38/77 /82/51 /96/63 article
Dawes, B. E., Kalveram, B., Ikegami, T., Juelich, T., Smith, J. K., Zhang, L., Park, A., Lee, B., Komeno, T., Furuta, Y. & Freiberg, A. N., Dec 1 2018, In: Scientific reports. 8, 1, 7604.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing
Ochoa, L. F., Kholodnykh, A., Villarreal, P., Tian, B., Pal, R., Freiberg, A. N., Brasier, A. R., Motamedi, M. & Vargas, G., Dec 1 2018, In: Scientific reports. 8, 1, 13348.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters
Atkins, C., Miao, J., Kalveram, B., Juelich, T., Smith, J. K., Perez, D., Zhang, L., Westover, J. L. B., Van Wettere, A. J., Gowen, B. B., Wang, Z. & Freiberg, A. N., Nov 22 2018, In: Journal of Infectious Diseases. 218, p. S438-S447Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Human neural stem cell-derived neuron/astrocyte co-cultures respond to la Crosse virus infection with proinflammatory cytokines and chemokines
Dawes, B. E., Gao, J., Atkins, C., Nelson, J. T., Johnson, K., Wu, P. & Freiberg, A. N., Nov 15 2018, In: Journal of neuroinflammation. 15, 1, 315.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Phosphorylated VP30 of marburg virus is a repressor of transcription
Tigabu, B., Ramanathan, P., Ivanov, A., Lin, X., Ilinykh, P. A., Parry, C. S., Freiberg, A. N., Nekhai, S. & Bukreyev, A., Nov 1 2018, In: Journal of virology. 92, 21, e00426.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Experimental Infection of Syrian Hamsters with Aerosolized Nipah Virus
Escaffre, O., Hill, T., Ikegami, T., Juelich, T. L., Smith, J. K., Zhang, L., Perez, D. E., Atkins, C., Park, A., Lawrence, W. S., Sivasubramani, S. K., Peel, J. E., Peterson, J., Lee, B. & Freiberg, A. N., Oct 5 2018, In: Journal of Infectious Diseases. 218, 10, p. 1602-1610 9 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Efficacy of tilorone dihydrochloride against ebola virus infection
Ekins, S., Lingerfelt, M. A., Comer, J. E., Freiberg, A. N., Mirsalis, J. C., O’Loughlin, K., Harutyunyan, A., McFarlane, C., Green, C. E. & Madrid, P. B., Feb 2018, In: Antimicrobial agents and chemotherapy. 62, 2, e01711-17.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
2017
Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain
Ly, H. J., Nishiyama, S., Lokugamage, N., Smith, J. K., Zhang, L., Perez, D., Juelich, T. L., Freiberg, A. N. & Ikegami, T., Dec 4 2017, In: Vaccine. 35, 48, p. 6634-6642 9 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection
McAuley, A. J., Sawatsky, B., Ksiazek, T., Torres, M., Korva, M., Lotrič-Furlan, S., Avšič-Županc, T., Von Messling, V., Holbrook, M. R., Freiberg, A. N., Beasley, D. W. C. & Bente, D. A., Dec 1 2017, In: npj Vaccines. 2, 1, 9.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Distinct virulence of Rift Valley fever phlebovirus strains from different genetic lineages in a mouse model
Ikegami, T., Balogh, A., Nishiyama, S., Lokugamage, N., Saito, T. B., Morrill, J. C., Shivanna, V., Indran, S. V., Zhang, L., Smith, J. K., Perez, D., Juelich, T. L., Morozov, I., Wilson, W. C., Freiberg, A. N. & Richt, J. A., Dec 2017, In: PloS one. 12, 12, e0189250.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
The host E3-ubiquitin ligase TRIM6 ubiquitinates the Ebola virus VP35 protein and promotes virus replication
Bharaj, P., Atkins, C., Luthra, P., Giraldo, M. I., Dawes, B. E., Miorin, L., Johnson, J. R., Krogan, N. J., Basler, C. F., Freiberg, A. N. & Rajsbaum, R., Sep 1 2017, In: Journal of virology. 91, 18, e00833-17.Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Contribution of human lung parenchyma and leukocyte influx to oxidative stress and immune systemmediated pathology following Nipah virus infection
Escaffre, O., Saito, T., Juelich, T. L., Ikegami, T., Smith, J. K., Perez, D. D., Atkins, C., Levine, C. B., Huante, M., Nusbaum, R. J., Endsley, J. J., Freiberg, A. N. & Rockx, B., Aug 1 2017, In: Journal of virology. 91, 15, e00275-17.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Efficient and robust Paramyxoviridae reverse genetics systems
Beaty, S. M., Park, A., Won, S. T., Hong, P., Lyons, M., Vigant, F., Freiberg, A. N., ten Oever, B. R., Paul Duprex, W. & Lee, B., Mar 1 2017, In: mSphere. 2, 2, e00376-16.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses
Bazhanov, N., Escaffre, O., Freiberg, A. N., Garofalo, R. P. & Casola, A., Jan 20 2017, In: Scientific reports. 7, 41029.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
2016
The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response
Bharaj, P., Wang, Y. E., Dawes, B. E., Yun, T. E., Park, A., Yen, B., Basler, C. F., Freiberg, A. N., Lee, B. & Rajsbaum, R., Sep 2016, In: PLoS pathogens. 12, 9, e1005880.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
Antiviral effect of ranpirnase against Ebola virus
Hodge, T., Draper, K., Brasel, T., Freiberg, A., Squiquera, L., Sidransky, D., Sulley, J. & Taxman, D. J., Aug 1 2016, In: Antiviral research. 132, p. 210-218 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
N-glycans on the rift valley fever virus envelope glycoproteins Gn and Gc redundantly support viral infection via DC-SIGN
Phoenix, I., Nishiyama, S., Lokugamage, N., Hill, T. E., Huante, M. B., Slack, O. A. L., Carpio, V. H., Freiberg, A. N. & Ikegami, T., May 23 2016, In: Viruses. 8, 5Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
ISG15 deficiency and increased viral resistance in humans but not mice
Speer, S. D., Li, Z., Buta, S., Payelle-Brogard, B., Qian, L., Vigant, F., Rubino, E., Gardner, T. J., Wedeking, T., Hermann, M., Duehr, J., Sanal, O., Tezcan, I., Mansouri, N., Tabarsi, P., Mansouri, D., Francois-Newton, V., Daussy, C. F., Rodriguez, M. R. & Lenschow, D. J. & 7 others, , May 19 2016, In: Nature communications. 7, 11496.Research output: Contribution to journal › Article › peer-review
Open Access80 Scopus citations -
Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway
Park, A., Yun, T., Vigant, F., Pernet, O., Won, S. T., Dawes, B. E., Bartkowski, W., Freiberg, A. N. & Lee, B., May 2016, In: PLoS pathogens. 12, 5, e1005659.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
Optimized P2A for reporter gene insertion into nipah virus results in efficient ribosomal skipping and wild-type lethality
Park, A., Yun, T., Hill, T. E., Ikegami, T., Juelich, T. L., Smith, J. K., Zhang, L., Freiberg, A. N. & Lee, B., Apr 2016, In: Journal of General Virology. 97, 4, p. 839-843 5 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2015
Bolstering Components of the Immune Response Compromised by Prior Exposure to Adenovirus: Guided Formulation Development for a Nasal Ebola Vaccine
Choi, J. H., Schafer, S. C., Freiberg, A. N. & Croyle, M. A., Aug 3 2015, In: Molecular Pharmaceutics. 12, 8, p. 2697-2711 15 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations