Alan Barrett

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Alan Barrett, PhD

Director, The Sealy Institute of Vaccine Sciences

1979 …2024

Research activity per year

Personal profile

Research Strategic Pillar

Dr. Randall Urban, VP and Chief Research Officer, has determined that UTMB research should be prioritized into six health communities. This researcher has received the following badge(s):

Research interests

Our laboratory is undertaking basic research on the development of vaccines against the flavivirus diseases. This includes West Nile, Japanese encephalitis, yellow fever and dengue. We undertake studies on the excellent yellow fever 17D vaccine as a model to understand the molecular basis of attenuation of this vaccine. This is of major importance as the 17D vaccine virus is being used as an attenuated backbone to generate chimeric vaccine viruses against other flavivirus diseases, including dengue and Japanese encephalitis. In addition, recombinant DNA technology and infectious clone technology/reverse genetics are being used to identify molecular determinants of virulence of yellow fever, West Nile and Japanese encephalitis viruses with the aim of mutating these virulence determinants to develop candidate attenuated vaccine strains. We also investigate the molecular epidemiology of various flaviviruses (yellow fever, West Nile, Japanese encephalitis, and St Louis encephalitis viruses).

Research Strategic Pillar Keywords

  • Brain Health
  • Life Span Health
  • Infectious/ Immunological Health
  • Specialized Health

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Collaborations and top research areas from the last five years

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  • Lassa fever research priorities: towards effective medical countermeasures by the end of the decade

    Moore, K. A., Ostrowsky, J. T., Mehr, A. J., Johnson, R. A., Ulrich, A. K., Moua, N. M., Fay, P. C., Hart, P. J., Golding, J. P., Benassi, V., Preziosi, M. P., Adetifa, I. M., Akpede, G. O., Ampofo, W. K., Asogun, D. A., Barrett, A. D. T., Bausch, D. G., de Coster, I., Emperador, D. M. & Feldmann, H. & 12 others, Fichet-Calvet, E., Formenty, P. B. H., Garry, R. F., Grant, D. S., Günther, S., Gupta, S. B., Jaspard, M., Mazzola, L. T., Okogbenin, S. A., Roth, C., Schmaljohn, C. S. & Osterholm, M. T., Nov 2024, In: The Lancet Infectious Diseases. 24, 11, p. e696-e706

    Research output: Contribution to journal › Review article › peer-review

  • Vaccine value profile for Chikungunya

    Flandes, X., Hansen, C. A., Palani, S., Abbas, K., Bennett, C., Caro, W. P., Hutubessy, R., Khazhidinov, K., Lambach, P., Maure, C., Marshall, C., Rojas, D. P., Rosewell, A., Sahastrabuddhe, S., Tufet, M., Wilder-Smith, A., Beasley, D. W. C., Bourne, N. & Barrett, A. D. T., Jul 25 2024, In: Vaccine. 42, 19, p. S9-S24

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Polio endgame finish is in sight

    Barrett, A. D. T., Jul 6 2023, In: Nature. 619, 7968, p. 36-38 3 p.

    Research output: Contribution to journal › Comment/debate › peer-review

  • Blocking NS3–NS4B interaction inhibits dengue virus in non-human primates

    Goethals, O., Kaptein, S. J. F., Kesteleyn, B., Bonfanti, J. F., Van Wesenbeeck, L., Bardiot, D., Verschoor, E. J., Verstrepen, B. E., Fagrouch, Z., Putnak, J. R., Kiemel, D., Ackaert, O., Straetemans, R., Lachau-Durand, S., Geluykens, P., Crabbe, M., Thys, K., Stoops, B., Lenz, O. & Tambuyzer, L. & 24 others, De Meyer, S., Dallmeier, K., McCracken, M. K., Gromowski, G. D., Rutvisuttinunt, W., Jarman, R. G., Karasavvas, N., Touret, F., Querat, G., de Lamballerie, X., Chatel-Chaix, L., Milligan, G. N., Beasley, D. W. C., Bourne, N., Barrett, A. D. T., Marchand, A., Jonckers, T. H. M., Raboisson, P., Simmen, K., Chaltin, P., Bartenschlager, R., Bogers, W. M., Neyts, J. & Van Loock, M., Mar 23 2023, In: Nature. 615, 7953, p. 678-686 9 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Differences in Genetic Diversity of Mammalian Tick-Borne Flaviviruses

    Carpio, K. L., Thompson, J. K., Widen, S. G., Smith, J. K., Juelich, T. L., Clements, D. E., Freiberg, A. N. & Barrett, A. D. T., Feb 2023, In: Viruses. 15, 2, 281.

    Research output: Contribution to journal › Article › peer-review

    Open Access
View all 361 Research outputs